diff --git a/RFM69.cpp b/RFM69.cpp
index d2aef58..f9998da 100644
--- a/RFM69.cpp
+++ b/RFM69.cpp
@@ -371,7 +371,7 @@ void RFM69::interruptHandler() {
 }
 
 // internal function
-void RFM69::isr0() { _haveData = true; }
+ISR_PREFIX void RFM69::isr0() { _haveData = true; }
 
 // internal function
 void RFM69::receiveBegin() {
diff --git a/RFM69.h b/RFM69.h
index e82dd6a..8289deb 100644
--- a/RFM69.h
+++ b/RFM69.h
@@ -68,6 +68,12 @@
  #endif
 #endif
 
+#if defined(ESP8266) || defined(ESP32)
+  #define ISR_PREFIX ICACHE_RAM_ATTR
+#else
+  #define ISR_PREFIX
+#endif
+
 // digitalPinToInterrupt is not available prior to Arduino 1.5.6 and 1.0.6
 // See http://arduino.cc/en/Reference/attachInterrupt
 #ifndef NOT_AN_INTERRUPT